Category: Publications

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations (Nature Protocols 2015)

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations Katarzyna Adamala, Aaron E Engelhart (Shared First Author), Neha P Kamat, Lin Jin, and Jack W Szostak Nature Protocols, 2015, 10(6), pp 927-938. doi:10.1038/nprot.2015.054 Publisher | ResearchGate | PubMed | Google Scholar […]

Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension (JACS 2015)

Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension Katarzyna Adamala, Aaron E. Engelhart, and Jack W. Szostak Journal of the American Chemical Society, 2015, 137(1), pp 483-489. doi: 10.1021/ja511564d Publisher | ResearchGate | PubMed | Google Scholar Scientific Abstract The earliest […]

Structural insights into the effects of 2′-5′ linkages on the RNA duplex (PNAS 2014)

Structural insights into the effects of 2′-5′ linkages on the RNA duplex Jia Sheng, Li Li, Aaron E. Engelhart, Jianhua Gan, Jiawei Wang, and Jack W. Szostak Proceedings of the National Academy of Sciences of the United States of America, 2014, 118 (8), pp 3050-3055. […]

Ester formation and hydrolysis during wet–dry cycles: Generation of far-from-equilibrium polymers in a model prebiotic reaction (Macromolecules 2014)

Ester Formation and Hydrolysis during Wet–Dry Cycles: Generation of Far-from-Equilibrium Polymers in a Model Prebiotic Reaction Irena Mamajanov, Patrick J. MacDonald, Jingya Ying, Daniel M. Duncanson, Garrett R. Dowdy, Chelsea A. Walker, Aaron E. Engelhart, Facundo M. Fernández, Martha A. Grover, Nicholas V. Hud, and […]

Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity (Nature Chemistry 2013)

Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity Aaron E. Engelhart, Matthew W. Powner & Jack W. Szostak Nature Chemistry, 2013, 5 (5), pp 390–394. doi: 10.1038/nchem.1623 Publisher | ResearchGate | PubMed | Google Scholar Featured in: News and Views | Nature […]

Nonenzymatic ligation of DNA with a reversible step and a final linkage that can be used in PCR (ChemBioChem 2012)

Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR Aaron E. Engelhart, Brian J. Cafferty, C. Denise Okafor, Michael C. Chen,  Loren Dean Williams, David G. Lynn and Nicholas V. Hud ChemBioChem, 2012, 13 (8), pp […]

DNA and RNA in anhydrous media: duplex, triplex, and G-Quadruplex secondary structures in a deep eutectic solvent (Angewandte Chemie 2010)

DNA and RNA in Anhydrous Media: Duplex, Triplex, and G-Quadruplex Secondary Structures in a Deep Eutectic Solvent (featured on Frontispiece) Irena Mamajanov, Aaron E. Engelhart, Heather D. Bean and Nicholas V. Hud Angewandte Chemie International Edition in English, 2010, 49 (36), pp 6310-6314. doi: 10.1002/anie.201001561 […]

Primitive genetic polymers (Cold Spring Harbor Perspectives in Biology 2010)

Primitive Genetic Polymers Aaron E. Engelhart and Nicholas V. Hud Cold Spring Harbor Perspectives in Biology, 2010. doi: 10.1101/cshperspect.a002196 Publisher | ResearchGate | PubMed | Google Scholar Scientific Abstract Since the structure of DNA was elucidated more than 50 years ago, Watson-Crick base pairing has […]

Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world (PNAS 2010)

Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world Eric D. Horowitz, Aaron E. Engelhart (Shared first author), Michael C. Chen, Kaycee A. Quarles, Michael W. Smith, David G. Lynn, and Nicholas V. Hud Proceedings of the […]

Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites (J. Biol. Chem. 2009)

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites Albert G. Tsai, Aaron E. Engelhart, Ma’mon M. Hatmal, Sabrina I. Houston, Nicholas V. Hud, Ian S. Haworth, and Michael R. Lieber Journal of Biological Chemistry, 2009, 284, pp 7157-7164. doi: 10.1074/jbc.M806866200 Publisher | […]