Postdoctoral positions available – click here!

My publications are listed below. The title of each links to a page with more detailed information. I have written goldy leaning on DNAabstracts targeted to the lay public for each publication, which can be found at each publication’s webpage. Please feel free to contact me with any questions about my work.

Full product list: google scholar.

Journal Article

1    Aufdembrink, L. M., Khan, P., Gaut, N. J., Adamala, K. P., & Engelhart, A. E. (2020). Highly specific, multiplexed isothermal pathogen detection with fluorescent aptamer readout. RNA, 26(9), 1283-1290.  10.1261/rna.075192.120

2    Hoog, T. G., Aufdembrink, L. M., Gaut, N. J., Sung, R.-J., Adamala, K. P., & Engelhart, A. E. (2020). Rapid deployment of smartphone-based augmented reality tools for field and online education in structural biology. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 48(5), 448-451.  10.1002/bmb.21396

3    Gaut, N. J., Gomez-Garcia, J., Heili, J. M., Cash, B., Han, Q., Engelhart, A. E., & Adamala, K. P. (2019). Differentiation of Pluripotent Synthetic Minimal Cells via Genetic Circuits and Programmable Mating. bioRxiv, 712968.

4    Hoog, T. G., Pawlak, M. R., Aufdembrink, L. M., Bachan, B. R., Galles, M. B., Bense, N. B., . . . Engelhart, A. E. (2019). DNA transistors switched by the Hofmeister effect. bioRxiv, 784561.

5    Aufdembrink, L. M., Hoog, T. G., Pawlak, M. R., Bachan, B. F., Heili, J. M., & Engelhart, A. E. (2019). Methods for thermal denaturation studies of nucleic acids in complex with fluorogenic dyes. Methods in enzymology, 623, 23–43.

6    Jin, L., Engelhart, A. E., Zhang, W., Adamala, K., & Szostak, J. W. (2018). Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron (II). Journal of the American Chemical Society, 140(44), 15016–15021.

7    Jin, L., Engelhart, A. E., Adamala, K. P., & Szostak, J. W. (2018). Preparation, purification, and use of fatty acid-containing liposomes. JoVE (Journal of Visualized Experiments)(132), e57324.

8    Heili, J. M., Gomez-Garcia, J., Gaut, N. J., Cash, B. W., Aufdembrink, L. M., Heffron, B. A., . . . Engelhart, A. E. (2018). Real-time visualization of in vitro transcription of a fluorescent RNA aptamer: An experiment for the upper-division undergraduate or first-year graduate laboratory. Journal of Chemical Education, 95(10), 1867–1871.

9    Engelhart, A. E. (2017). RNA Imaging: A Tale of Two G-quadruplexes. Nature Chemical Biology, 13(11), 1140.

10 Engelhart, A. E., Adamala, K. P., & Szostak, J. W. (2016). A simple physical mechanism enables homeostasis in primitive cells. Nature Chemistry, 8(5), 448.

11 Adamala, K. P., Engelhart, A. E., & Szostak, J. W. (2016). Collaboration between primitive cell membranes and soluble catalysts. Nature Communications, 7, 11041.

12 Adamala, K., Engelhart, A. E., Kamat, N. P., Jin, L., & Szostak, J. W. (2015). Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nature Protocols, 10(6), 927.

13 Mamajanov, I., MacDonald, P. J., Ying, J., Duncanson, D. M., Dowdy, G. R., Walker, C. A., . . . others (2014). Ester formation and hydrolysis during wet–dry cycles: generation of far-from-equilibrium polymers in a model prebiotic reaction. Macromolecules, 47(4), 1334–1343.

14 Adamala, K., Engelhart, A. E., & Szostak, J. W. (2014). Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. Journal of the American Chemical Society, 137(1), 483–489.

15 Sheng, J., Li, L., Engelhart, A. E., Gan, J., Wang, J., & Szostak, J. W. (2014). Structural insights into the effects of 2′-5′ linkages on the RNA duplex. Proceedings of the National Academy of Sciences, 111(8), 3050–3055.

16 Engelhart, A. E., Powner, M. W., & Szostak, J. W. (2013). Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity. Nature Chemistry, 5(5), 390.

17 Engelhart, A. E., Cafferty, B. J., Okafor, C. D., Chen, M. C., Williams, L. D., Lynn, D. G., & Hud, N. V. (2012). Nonenzymatic ligation of DNA with a reversible step and a final linkage that can be used in PCR. ChemBioChem, 13(8), 1121–1124.

18 Mamajanov, I., Engelhart, A. E., Bean, H. D., & Hud, N. V. (2010). DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent. Angewandte Chemie International Edition, 49(36), 6310–6314.

19 Horowitz, E. D., Engelhart, A. E., Chen, M. C., Quarles, K. A., Smith, M. W., Lynn, D. G., & Hud, N. V. (2010). Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world. Proceedings of the National Academy of Sciences, 107(12), 5288–5293.

20 Engelhart, A. E., & Hud, N. V. (2010). Primitive genetic polymers. Cold Spring Harbor perspectives in biology, 2(12), a002196.

21 Tsai, A. G., Engelhart, A. E., Ma’mon, M. H., Houston, S. I., Hud, N. V., Haworth, I. S., & Lieber, M. R. (2009). Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. Journal of Biological Chemistry, 284(11), 7157–7164.

22 Engelhart, A. E., Morton, T. H., & Hud, N. V. (2009). Evidence of strong hydrogen bonding by 8-aminoguanine. Chemical Communications(6), 647–649.

23 Persil \cCetinkol, \”Ozg\”ul, Engelhart, A. E., Nanjunda, R. K., Wilson, W. D., & Hud, N. V. (2008). Submicromolar, Selective G-Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines. ChemBioChem, 9(12), 1889–1892.

Book Chapter

1    Hud, N. V., & Engelhart, A. E. (2009). Nucleic Acid-Metal Ion Interactions vol. 14, 75–117. Royal Society of Chemistry London.

2    Engelhart, A. E., Plavec, J., Persil, O., & Hud, N. V. (2008). Metal Ion Interactions With G-quadruplex Structures 114–149. Nucleic acid–metal ion interactions.


1    Khan, P., Aufdembrink, L. M., & Engelhart, A. E. (2020). Isothermal SARS-CoV-2 Diagnostics: Tools for Enabling Distributed Pandemic Testing as a Means of Supporting Safe Reopenings 11th ed., vol. 9, 2861-2880. ACS SYNTHETIC BIOLOGY.  10.1021/acssynbio.0c00359