Postdoctoral positions available – click here!

My publications are listed below. The title of each links to a page with more detailed information. I have written goldy leaning on DNAabstracts targeted to the lay public for each publication, which can be found at each publication’s webpage. Please feel free to contact me with any questions about my work.

Peer-Reviewed

  1. Adamala, KP; Engelhart, AE (Shared First Author); Szostak, JW. “Collaboration between primitive cell membranes and soluble catalysts.” Nature Comms., doi:10.1038/ncomms11041.
  2. Engelhart, AE; Adamala, KP (Shared First Author); Szostak, JW. “A simple physical mechanism enables homeostasis in primitive cells.” Nature Chem., doi:10.1038/nchem.2475. Featured in Chemistry World, Genetic Engineering and Biotechnology News, MGH Press Release.
  3. Adamala, K; Engelhart, AE (Shared First Author); Kamat, NP; Jin, L; Szostak, JW. “Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.” Nature Prot., 2015, 10(6), pp. 927-938. Selected to be featured as free article for first week of publication.
  4. Adamala, K; Engelhart, AE; Szostak, JW. “Generation of Functional RNAs From Inactive Oligonucleotide Complexes by Non-Enzymatic Primer Extension.” J. Am. Chem. Soc., 2015, 137(1), pp 483-489.
  5. Sheng, J; Li, L; Engelhart, AE; Gan, J; Wang, J; Szostak, JW. “Structural insights into the effects of 2′-5′ linkages on the RNA duplex.” Proc. Nat. Acad. Sci. USA (2014) 111:3050-3055.
  6. Mamajanov, I; Ying, J; Duncanson, D; MacDonald, P; Walker, C; Engelhart, AE; Fernandez, F; Grover, M; Dowdy, G; Hud, NV; Schork, FJ. “Ester Formation and Hydrolysis During Wet-Dry Cycles: Generation of Far-From-Equilibrium Polymers in a Model Prebiotic Reaction.” Macromolecules (2014) 47:1334-1343.
  7. Engelhart, AE; Powner, MW; and Szostak, JW. “Functional RNAs exhibit tolerance for non-heritable 2′-5′ versus 3′-5′ backbone heterogeneity.” Nature Chem. (2013) 5:390-394. Featured in News and Views, C&E News.
  8. Engelhart, AE; Cafferty, BJ; Okafor, CD; Williams, LD; Lynn, DG; and Hud, NV. “Nonenzymatic ligation of DNA with a reversible step and a final linkage that can be used in PCR.” ChemBioChem (2012) 13:1121-1124.
  9. Mamajanov, I; Engelhart, AE; Bean, HD; Hud, NV. “DNA and RNA in anhydrous media: duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent.” Angew. Chem. Intl. Ed. Engl. (2010) 122:6454-6458.
  10. Horowitz, EH; Engelhart, AE (Shared First Author); Quarles, KA; Smith, MW; Chen, MC; Lynn, DG. “Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world.” Proc. Nat. Acad. Sci. USA (2010) 107:5288-5293.
  11. Tsai, AG; Engelhart, AE; Hatmal, MM; Houston, SI; Hud, NV; Haworth, IS; Lieber, MR. “Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites.” J. Biol. Chem. (2009) 284:7157-7164.
  12. Engelhart, AE; Morton, TH; Hud, NV. “Evidence of strong hydrogen bonding by 8-amino-guanine.” ChemComm. (2009) 647-649. (Cover article)
  13. Cetinkol, ÖP; Engelhart, AE (Shared First Author); Nanjunda, RK; Wilson, WD; Hud, NV. “Submicromolar, selective G-quadruplex ligands from one pot: thermodynamic and structural studies of human telomeric DNA binding by azacyanines.” ChemBioChem (2008). 9:1889-1892.

Reviews and Book Chapters

  1. Engelhart, AE and Hud, NV. “Primitive genetic polymers.” Cold Spring Harb. Perspect. Biol. (2010) DOI: 10.1101/cshperspect.a002196.
  2. Hud, NV and Engelhart, AE. “Sequence-specific DNA-metal ion interactions.” in Nucleic Acid-Metal Ion Interactions. (2009) RSC (London).
  3. Engelhart, AE; Plavec, J; Persil, ÖP; and Hud, NV. “Metal ion interactions with G quadruplex structures.” in Nucleic Acid-Metal Ion Interactions. (2009) RSC (London).