Lauren M Aufdembrink, Pavana Khan, Nathaniel J Gaut, Katarzyna P Adamala, Aaron E Engelhart
RNA 2020. 26: 1283-1290
Category: Publications
Mars as a Prebiotic Chemistry Laboratory: A Martian RNA World?
T Hoog, N Gaut, MR Pawlak, BF Bachan, AE Engelhart Mars Extant Life: What’s Next? Held 5-8 November, 2019 in Carlsbad, New Mexico. LPI Contribution No. 2108, 2019, id.5098 Here we report our investigations of the behavior of nucleic acids in the presence of high […]
Methods for thermal denaturation studies of nucleic acids in complex with fluorogenic dyes
Lauren M Aufdembrink, Tanner G Hoog, Matthew R Pawlak, Benjamin F Bachan, Joseph M Heili, Aaron E Engelhart Methods in Enzymology Volume 623, 2019, Pages 23-43 Thermal denaturation is a common technique in the biophysical study of nucleic acids. These experiments are typically performed by […]
The RNA World on Mars
Tanner G. Hoog, Matthew R. Pawlak, Nathaniel J. Gaut, Gloria C. Baxter, Thomas A. Bethel, Katarzyna P. Adamala & Aaron E. Engelhart
The Astrobiology Science Conference (AbSciCon) 2019, Pages 403-8
Catalysis of template-directed nonenzymatic RNA copying by Iron (II)
Lin Jin, Aaron E Engelhart, Weicheng Zhang, Katarzyna Adamala, Jack W Szostak J. Am. Chem. Soc. 2018, 140, 44, 15016–15021 The study of nonenzymatic template-directed RNA copying is the experimental basis for the search for chemistry and reaction conditions consistent with prebiotic RNA replication. The […]
Real-Time Visualization of in Vitro Transcription of a Fluorescent RNA Aptamer: An Experiment for the Upper-Division Undergraduate or First-Year Graduate Laboratory
Joseph M Heili, Jose Gomez-Garcia, Nathaniel J Gaut, Brock W Cash, Lauren M Aufdembrink, Brent A Heffron, Joshua D Shirley, Erin E Carlson, Katarzyna P Adamala, Aaron E Engelhart
Journal of Chemical Education, 2018, 95, 10, 1867–1871
Preparation, Purification, and Use of Fatty Acid-containing Liposomes (Journal of Visualized Experiments 2018)
Preparation, Purification, and Use of Fatty Acid-containing Liposomes (News and Views) Aaron E. Engelhart Journal of Visualized Experiments, 2018. doi:10.3791/57324 Publisher | ResearchGate | PubMed | Google Scholar | Free Readcube Link to Paper Liposomes containing single-chain amphiphiles, particularly fatty acids, exhibit distinct properties compared […]
RNA imaging: A tale of two G-quadruplexes (Nature Chemical Biology 2017) (News and Views)
RNA imaging: A tale of two G-quadruplexes (News and Views) Aaron E. Engelhart Nature Chemical Biology, 2017. doi:10.1038/nchembio.2492 Publisher | ResearchGate | PubMed | Google Scholar | Free Readcube Link to Paper This News and Views piece from our lab accompanies the the publication of […]
Collaboration between primitive cell membranes and soluble catalysts
Katarzyna P. Adamala, Aaron E. Engelhart (joint first author), and Jack W. Szostak
Nature Communications, 2016.
A simple physical mechanism enables homeostasis in primitive cells (Nature Chemistry 2016)
A simple physical mechanism enables homeostasis in primitive cells Aaron E. Engelhart, Katarzyna P. Adamala, and Jack W. Szostak Nature Chemistry, 2016. doi:10.1038/nchem.2475 Publisher | ResearchGate | PubMed | Google Scholar Featured in: Chemistry World | Genetic Engineering and Biotechnology News | MGH Press Release Scientific Abstract The emergence […]